Major FPS drops. Resulting sound lags that makes the music and voice lines sound slow and choppy. Some epic songs will just turn into garbage when played in half speed. Generally, the game is playable, but hardly enjoyable.
With Citra, you basically have to play the entire with 50% speed, making this lengthy and long game even more time consuming. This condition could be slightly improved by decreasing the internal resolution in the citra configuration then minimizing the citra screen, which makes all non-3d gameplay (such as conversation scenes) stick to a general 80~90% speed.